WARNING: Discuss the risks and benefits of use for darbepoetin alfa with your doctor, as this medication may rarely cause very serious (possibly fatal) side effects, including blood clots. Darbepoetin is marketed by Amgen under the trade name Aranesp. More About Darbepoetin Alfa. The advisory recommended caution in using these agents in cancer patients receiving chemotherapy or off chemotherapy, and indicated a lack of clinical evidence to support improvements in quality of life or transfusion requirements in these settings.
PRECAUTIONS: Before using darbepoetin alfa, tell your doctor or pharmacist if you are allergic to it; or to other drugs that cause more red blood cells to be made (e.g., epoetin alfa); or to products containing human albumin; or if you have any other allergies. Tell your doctor if your symptoms do not improve or if they worsen. on March 9, 2007, and a clinical alert for doctors on February 16, 2007, about the use of erythropoeisis-stimulating agents (ESAs) such as epoetin alfa (marketed as Epogen) and darbepoetin alfa. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. It stimulates erythropoiesis (increases red blood cell levels) by the same mechanism as rHuEpo (binding and activating the Epo receptor) and is used to treat anemia, commonly associated with chronic kidney failure and cancer chemotherapy. The DAHANCA 10 data monitoring committee found that 3-year loco-regional control in subjects treated with Aranesp was significantly worse than for those not receiving Aranesp (p=0.01). You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. Find Clinical Trials for Darbepoetin Alfa - Check for trials from NCI's list of cancer clinical trials now accepting patients. Prerenal kidney failure is caused by blood loss, dehydration, Aranesp (darbepoetin alfa) is an erythropoiesis-stimulating protein that is produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.Aranesp is a 165 … Selected from data included with permission and copyrighted by First Databank, Inc. DESCRIPTION. and a collection of links to more information about the use of If high blood pressure develops or worsens, follow your doctor's instructions about diet changes and starting or adjusting your high blood pressure medication. Many people using this medication do not have serious side effects.Darbepoetin alfa may sometimes cause or worsen high blood pressure, especially in patients with long-term kidney failure. ©1996-2020 MedicineNet, Inc. All rights reserved. Darbepoetin alfa is used to treat nonregenerative anemia. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else.
This is the world's first follow-on biologic of darbepoetin alfa. It works by signaling the bone marrow to make more red blood cells. This product may contain inactive ingredients (such as polysorbate, latex), which can cause allergic reactions or other problems. Therefore, your doctor should have special training in order to prescribe this medication and be able to discuss with you the risks and benefits of this medication. Consult your pharmacist or local waste disposal company. rhabdomyolysis, If this occurs with darbepoetin alfa treatment, it may be possible to get pregnant while using this medication. Get medical help right away if you notice any of the following rare but very serious side effects: pain/redness/swelling/weakness of the arms or legs, calf pain/swelling that is warm to the touch, new/worsening shortness of breath, coughing up blood, sudden vision changes, slurred speech, confusion, weakness on one side of the body, sudden severe headache, chest/jaw/left arm pain, irregular heartbeat, fainting, blood clots in your hemodialysis vascular access site.Rarely, this medication may suddenly stop working well after a period of time because your body may make antibodies that reduce the effectiveness of darbepoetin alfa, and a very serious anemia can result. It also helps to reduce the need for blood transfusions. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
In response to these advisories, the FDA released a Public Health Advisory Sickle cell disease is named after a farming tool.
It is not a substitute for medical advice. Darbepoetin alfa is a second-generation ESA that is a supersialylated analogue of … According to the 2010 update to clinical practice guidelines from the American Society of Clinical Oncology (ASCO) and the American Society of Hematology (ASH), use of ESAs such as darbepoetin alfa in cancer patients is appropriate when following stipulations outlined in FDA-approved labeling. The medication was approved in September 2001, by the US Food and Drug Administration for treatment of anemia in patients with chronic kidney failure by intravenous or subcutaneous injection. Check with your doctor right away if you have a … Sign Up for MedicineNet Newsletters! Discuss the need for birth control with your doctor.It is not known whether this drug passes into breast milk. In some women of child-bearing age, menstrual periods have resumed during treatment with a similar drug (epoetin alfa).  A recent study has extended these findings to treatment of patients exhibiting cancer-related anemia (distinct from anemia resulting from chemotherapy). Medication Uses | How To Use | Side Effects | MISSED DOSE: If you miss a dose, use it as soon as you remember.
MedlinePlus Information on Darbepoetin Alfa - A lay language summary of important information about this drug that may include the following: Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. It has a 3-fold longer serum half-life compared to epoetin alpha and epoetin beta. Canada residents can call a provincial poison control center. Darbepoetin alfa may cause a serious type of allergic reaction called anaphylaxis. This can be life-threatening and requires immediate medical attention. It has been used to treat myelosuppression caused by disease or chemotherapy. Amgen sent a "dear doctor" letter in January, 2007, that highlighted results from a recent anemia of cancer trial, and warned doctors to consider use in that off-label indication with caution.
Darbepoetin is produced by recombinant DNA technology in modified Chinese hamster ovary cells.
Ask your doctor if you should learn how to monitor your own blood pressure. If you have any questions, ask your doctor or pharmacist.This medication is given as an injection under the skin or into a vein as directed by your doctor. Copyright(c) 2014 First Databank, Inc. Kidney failure can occur from an acute event or a chronic condition or disease. , Darbepoetin alfa binds to the erythropoietin receptor on erythroid progenitor cells, stimulating RBC production and differentiation.. what you should tell your doctor before using this drug. kidney stones.Treatment options included diet, medications, or dialysis. Important: The drug information on this page is meant to be educational. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Information last revised January 2014. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., complete blood count that includes hemoglobin and hematocrit, reticulocyte count) must be performed regularly to monitor your progress or check for side effects. , Darbepoetin alfa has black box warnings in the United States for increased risk of death, myocardial infarction, stroke, venous thromboembolism, thrombosis of vascular access, and tumor progression or recurrence. MedicineNet does not provide medical advice, diagnosis or treatment. GENERIC NAME: DARBEPOETIN ALFA - INJECTION (DAR-boh-poh-EE-tin AL-fuh). Consult your doctor before breast-feeding. Therefore, these patients should use caution and avoid activities such as driving or using machinery during this period. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. This document does not contain all possible drug interactions.
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